PROSTHETIC HEART VALVE MECHANICS


PROSTHETIC HEART VALVE MECHANICS

Strain in commercial grade bovine pericardium leaflets under diastolic pressure of 120 mmHg, as a function of collagen fibre patterns. Material properties calibrated from uniaxial and fatigue bulge loading.

Non-destructive optical analysis of commercial-grade bovine pericardium using in-house small angle light scattering (SALS). Contour plot shows heterogenous collagen fibre structure across patch, with alignment ranging from low to high (0.5 – 0.9).

Publications

[1] Gaul, R., Nolan, D. and Lally, C., 2017. Collagen fibre characterisation in arterial tissue under load using SALS. Journal of the Mechanical Behavior of Biomedical Materials, 75, pp.359-368. Available: 10.1016/j.jmbbm.2017.07.036

[2] Whelan, A., Williams, E., Nolan, D., Murphy, B., Gunning, P., O’Reilly, D. and Lally, C., 2020. Bovine Pericardium of High Fibre Dispersion Has High Fatigue Life and Increased Collagen Content; Potentially an Untapped Source of Heart Valve Leaflet Tissue. Annals of Biomedical Engineering, 49(3), pp.1022-1032. Available: 10.1007/s10439-020-02644-4