Dr. Alix Whelan
Postdoctoral Research Fellow

Collagen fibre-mediated fatigue mechanics of pericardium for use in Transcatheter Aortic Valve Replacements


[1] A. Whelan et al., "Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium", Journal of the Mechanical Behavior of Biomedical Materials, vol. 90, pp. 54-60, 2019. 10.1016/j.jmbbm.2018.09.038

[2] A. Whelan et al., "Bovine Pericardium of High Fibre Dispersion Has High Fatigue Life and Increased Collagen Content; Potentially an Untapped Source of Heart Valve Leaflet Tissue", Annals of Biomedical Engineering, vol. 49, no. 3, pp. 1022-1032, 2020. 10.1007/s10439-020-02644-4

[3] A. Whelan et al., "Collagen fibre-mediated mechanical damage increases calcification of bovine pericardium for use in bioprosthetic heart valves", Acta Biomaterialia, 2021. 10.1016/j.actbio.2021.04.046

[4] A. Whelan, G.  O'Brien, A.  Szagdaj, D.  O'Reilly and C.  Lally, "Investigation into early stage fatigue-damage accumulation in glutaraldehyde-fixed bovine pericardium using a novel equibiaxial bulge inflation system", Journal of the Mechanical Behavior of Biomedical Materials, vol. 121, p. 104588, 2021. 10.1016/j.jmbbm.2021.104588